期刊
ACS COMBINATORIAL SCIENCE
卷 16, 期 9, 页码 506-512出版社
AMER CHEMICAL SOC
DOI: 10.1021/co500085t
关键词
spirooxindole; pyrrolidine/pyrrolizidine/pyrrolothiazole; 1,3-dipolar cycloaddition; combinatorial synthesis
资金
- Project of Science and Technology of Xuzhou Government [XM13B070, XM12B012]
- Key Laboratory of Green Synthesis for Functional Materials of Jiangsu Province [K201309]
- Key Laboratory of Organic Synthesis of Jiangsu Province [KJS1010]
- Program of young visitor scholar in higher education institutions of China
- Xuzhou Medical College
A series of diverse polycyclic heterocycles containing spirooxindole, pyridine/thiophene, and pyrrolidine/pyrrolizidine/pyrrolothiazole rings have been synthesized through the 1,3-dipolar cydoaddition of azomethine ylides generated in situ by the condensation of dicarbonyl compounds (isatin or acenaphthenequinone) and secondary amino acids with dipolarophiles. The method is simple and provides diverse and biologically interesting products with excellent yields.
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