期刊
ACS COMBINATORIAL SCIENCE
卷 16, 期 3, 页码 139-145出版社
AMER CHEMICAL SOC
DOI: 10.1021/co400096c
关键词
dispiropyrrolizidine; three-component reaction; azomethine ylide; antitumor activity
资金
- National Natural Science Foundation of China [81102817]
- Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions [10KJA150049]
- Natural Science Foundation of the Jiangsu Province [BK2011422]
- Priority Academic Project Development of Jiangsu Higher Education Institutions
- Foundation of Key Laboratory of Organic Synthesis of Jiangsu Province [JSK1112]
An efficient and regioselective synthesis of novel functionalized dispiropyrrolizidine derivatives via a three-component [3 + 2] cycloaddition reaction of azomethine ylides is described. This protocol has the advantages of high efficiency, mild reaction conditions, a one-pot procedure, and convenient operation. Many of these compounds were evaluated for their antiproliferative properties in vitro against cancer cells and several compounds were found to have good activities.
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