期刊
ACS COMBINATORIAL SCIENCE
卷 15, 期 7, 页码 344-349出版社
AMER CHEMICAL SOC
DOI: 10.1021/co4000387
关键词
nitrile hydrozirconation-acylation-cyclization; cascade; spirooxindole
资金
- NIH/NIGMS CMLD program [P50GM067082, R21HL109654]
A library of spirooxindoles containing varied elements of structural and stereochemical diversity has been constructed via a three step, one pot nitrile hydrozirconation-acylation-cyclization reaction sequence from common acyclic indole intermediates. The resulting library was evaluated for novelty through comparison with MLSMR and Maybridge compound collections.
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