期刊
ACS COMBINATORIAL SCIENCE
卷 14, 期 10, 页码 551-557出版社
AMER CHEMICAL SOC
DOI: 10.1021/co300081k
关键词
multicomponent reactions; pyridine synthesis; [3+3]aza-annulations
资金
- MICINN [CTQ2009-12320-BQU]
- Universidad Complutense [GR35/10-A-920234]
The three-component formal [3 + 3] aza-annulation between chalcones, beta-ketoamides, and ammonium acetate in the presence of CAN as a Lewis acid affords good to excellent yields of highly substituted nicotinamides or their fused derivatives. This transformation leads to the formation of one C-C and two C-N bonds in a single synthetic operation and involves up to five individual steps.
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