期刊
ACS COMBINATORIAL SCIENCE
卷 14, 期 4, 页码 258-262出版社
AMER CHEMICAL SOC
DOI: 10.1021/co200165j
关键词
microwave-assisted organic synthesis; dielectric heating; venting while heating; sulfenylation; 3-arylthioindoles; indole
资金
- Ministero dell'Istruzione
- dell'Universita e della Ricerca [200879X9N9, RBFR10ZJQT]
- Universita La Sapienza (Finanziamento Progetti di Ricerca) [2011]
- FILAS (Finanziaria Laziale di Sviluppo) [2010]
- international FIRB [RBIN06E9Z8]
We report the first example of venting-while-heating microwave-assisted synthesis of a small library of 3-arylthioindoles. Compounds were prepared in excellent isolated yields (90-98%) within 4 min in a closed vessel by treating indoles with disulfides in the presence of sodium hydride in anhydrous N,N-dimethylformamide. The method was not affected by electron-donating and -withdrawing substituents both on 3-arylthio moiety and at 2- and 5-positions of the indole nucleus.
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