期刊
ACS COMBINATORIAL SCIENCE
卷 14, 期 1, 页码 1-4出版社
AMER CHEMICAL SOC
DOI: 10.1021/co200129t
关键词
amino acids; morpholines; piperazines; thiomorpholines; diastereoselective reaction
资金
- Department of Science and Technology, New Delhi, India
- CSIR
Diastereoselective trans-2,5-disubstituted amino acids derived diverse morpholines, piperazines and thiomorpholines were prepared in 30 min-1 h with high yields through iodine-mediated 6-exotrig type cyclization from a single common synthetic intermediate. The displacement of iodine with hydride ion gave a methyl substituent at the 2-position of morpholines which provides an additional opportunity for diversity oriented nucleophilic substitution on the rings as well as incorporation of substituents at the 5-position from amino acids constituents.
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