期刊
ACS COMBINATORIAL SCIENCE
卷 13, 期 2, 页码 181-185出版社
AMER CHEMICAL SOC
DOI: 10.1021/co100055x
关键词
multicomponent reaction; one-pot; cerium; ammonium nitrate; tetrahydropyridines; heterocycles
资金
- National Natural Science Foundation of China [20872025, 21072042]
- Nature Science Foundation of Hebei Province [B2008000149]
- Science Foundation of Hebei Normal University
A highly atom-economic one-pot synthesis of functionalized tetrahydropyridines by a multicomponent condensation reaction of beta-keto ester, two equivalents of aromatic aldehyde, and two equivalents of amine in the presence of a catalytic amount of cerium ammonium nitrate (CAN) is reported. In this way, a series of pharmacologically interesting substituted piperidine derivatives were obtained in moderate to good yields at room temperature.
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