期刊
ACS CATALYSIS
卷 8, 期 9, 页码 8369-8375出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.8b02939
关键词
C-H amidation; iron-catalysis; benzoxazolone; chemoselective; nitrene insertion; DFT calculations
资金
- DST, New Delhi [IF15-CH-179]
- DST-SERB [SB/S2/RJN-004/2015, PDF/2016/002053]
- NIPER-Raebareli
- DST, New Delhi
Herein, we report Fe-(III)(TPP)Cl as an effective catalyst for promoting arene C-H amidation through intramolecular cyclization of N-tosyloxyarylcarbamate substrates. The reaction proceeds via nitrene (outer sphere pathway) C(sp(2))-H insertion to yield benzoxazolones under external-oxidant-free conditions at ambient temperature. The method is operationally simple and scalable with high-functional-group tolerance. Preliminary experimental and computational data indicates involvement of electrophilic aromatic substitution mechanism for this aryl C-H amidation transformation, distinct from operating mechanism reported previously in aryl C-H amination using azide-based substrates.
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