期刊
ACS CATALYSIS
卷 4, 期 11, 页码 4070-4073出版社
AMER CHEMICAL SOC
DOI: 10.1021/cs501086f
关键词
DNA; hybrid catalyst; asymmetric catalysis; Friedel-Crafts reaction; direct ligand incorporation
资金
- Japan Science and Technology Corporation (JST)
- WPI program (iCeMS, Kyoto University)
We have developed a DNA-based hybrid catalyst containing an intrastrand bipyridine ligand through direct ligand incorporation and successfully performed asymmetric intramolecular FriedelCrafts alkylations. This is the first report on the DNA hybrid catalyst system where an intrastrand ligand is covalently introduced into the phosphate backbone. We have generated a series of active site to investigate the structural details of DNA hybrid catalysts and demonstrated that catalytic properties of DNA hybrid catalysts are governed by the disposition of the metal-binding site in the DNA duplex, the size of catalytic cavity, and the composition of nucleobases in the catalytic pocket.
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