期刊
ACS CATALYSIS
卷 4, 期 11, 页码 3972-3981出版社
AMER CHEMICAL SOC
DOI: 10.1021/cs501269d
关键词
alpha-alkyladion; hydrogen borrowing; alcohol; ketone; methanol
资金
- KAKENHI
- MEXT
This paper summarizes recent advances in a-alkylation reactions based on hydrogen borrowing methodologies using alcohol as an alkylating agent. This review provides a summary of recent progress toward the a-alkylation of carbonyl substrates, as well as relatively unactivated substrates bearing fewer acidic a-hydrogens, such as acetonitriles, acetamides, esters, methylpyrimidines, and methylquinolines. A summary of recent improvements in a-methylation strategies based on hydrogen borrowing methodologies has also been provided. Particular emphasis has been placed on highly practical and green chemistry approaches involving modified catalytic systems, including metal-supported heterogeneous catalysts and nanoparticle-based catalysts, as well as reactions conducted in the absence of a transition-metal catalyst. A review of recent achievements in methylation strategies using methanol as a methyl source, and their application to the a-methylation of ketones using transition-metal catalyzed hydrogen borrowing methodology, has also been documented.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据