期刊
ACS CATALYSIS
卷 4, 期 5, 页码 1349-1357出版社
AMER CHEMICAL SOC
DOI: 10.1021/cs4011502
关键词
alkyne reduction; palladium; N-heterocyclic carbene; NHC; transfer-hydrogenation
资金
- National Research School Combination Catalysis [2009-2013-UVA-Elsevier-02/03]
A convenient and easy-to-use protocol for the Z-selective transfer semihydrogenation of alkynes was developed, using ammonium formate as the hydrogen source and the easily prepared and commercially available, highly stable complex PdC1(eta(3)-C3H5)(IMes) (1) as the (pre)catalyst. Combined with triphenyl posphine as an additional ligand, this system provides a robust catalytic synthetic method that shows little to no over-reduction or isomerization after full substrate conversion. The system allows the direct use of solvents and reagents, as received from the supplier without drying or purification, thus providing a practical method for semihydrogenation of a broad range of alkynes. The mechanism behind these high and enhanced selectivities was determined through a set of kinetic experiments.
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