期刊
ACS CATALYSIS
卷 3, 期 10, 页码 2244-2247出版社
AMER CHEMICAL SOC
DOI: 10.1021/cs400591u
关键词
phosphoric acid; asymmetric; 2-aminobenzamide; dihydroquinazolinone; organocatalysis
资金
- National Natural Foundation of China [21272202, J1210042]
- Fundamental Research Funds for the Central Universities
The asymmetric condensation/amine addition cascade sequence of 2-aminobenzamides and aldehydes catalyzed by chiral spirocyclic SPINOL-phosphoric acids was realized. SPINOL-phosphoric acid 1j was found to be a general, highly enantioselective organocatalyst for such cascade reactions at room temperature, affording 2,3-dihydroquinazolinones in excellent yields (up to 99%) with good to excellent ee's (up to 98%). The best level of stereocontrol was obtained for aromatic aldehydes with an ortho substituent.
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