期刊
ACS CATALYSIS
卷 3, 期 11, 页码 2436-2439出版社
AMER CHEMICAL SOC
DOI: 10.1021/cs400535c
关键词
lactones; alcohol dehydrogenase; laccase-mediator system; cofactor regeneration; two liquid phase systems; biocatalysis; chemoenzymatic cascades
资金
- Deutsche Bundesstiftung Umwelt (DBU) [AZ 13261]
The oxidative lactonization of 1,4-, 1,5-, and 1,6-diols using horse liver alcohol dehydrogenase (HLADH) is reported. Molecular oxygen was used as terminal electron acceptor by utilization of the laccase-mediator concept to regenerate the oxidized nicotinamide cofactor and producing water as sole byproduct. Spontaneous hydrolysis of the lactone products was identified as a major limiting factor toward preparative application of the system, which can be alleviated by using a two liquid phase approach to extracting the product into an organic solvent.
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