期刊
ACS CATALYSIS
卷 3, 期 11, 页码 2536-2540出版社
AMER CHEMICAL SOC
DOI: 10.1021/cs400799n
关键词
alkylation; alcohol activation; hydrogen borrowing; palladium catalyst; amine synthesis
资金
- GSK-EDB Singapore Partnership for Green and Sustainable Manufacturing
- Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), Singapore
PdCl2 in the presence of dppe or Xantphos(t-Bu) as the ligand is found to be an efficient catalyst for the N-alkylation of various primary and cyclic secondary amines using primary alcohols at 90-130 degrees C under neat conditions. Interestingly, good to excellent yields were achieved when more challenging secondary alcohols were used as alkylating agents at 130-150 degrees C. The reaction could be easily scaled up, as demonstrated for a 10 mmol scale achieving yields up to 90% with a TON of 900.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据