期刊
ACS CATALYSIS
卷 3, 期 4, 页码 555-559出版社
AMER CHEMICAL SOC
DOI: 10.1021/cs400002d
关键词
asymmetric catalysis; biocatalysis; amination; omega-transaminase; aminochromane; aminotetraline
资金
- European Union [245144 (AmBioCas)]
- Austrian Science Fund (FWF) [W 901] Funding Source: researchfish
Various (S)-selective and (R)-selective omega-transaminases were investigated for the amination of 1- and 2-tetralone and derivatives as well as of 3- and 4-chromanone. All ketones tested were aminated to give the corresponding enantiopure amines (ee > 99%) employing at least one of the enzymes investigated. In most of the cases the (S)- as well as the (R)-enantiomer was obtained in optically pure form. The amination of 3-chromanone was performed on a 100 mg scale leading to optically pure (R)-3-aminochromane (ee > 99%) with complete conversion and 78% isolated yield.
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