期刊
ACS CATALYSIS
卷 3, 期 4, 页码 631-634出版社
AMER CHEMICAL SOC
DOI: 10.1021/cs4000574
关键词
monofluoromethylation; copper catalysis; (2-pyridy)sulfonyl group; cross-coupling; fluorine
资金
- National Basic Research Program of China [2012CB821600, 2012CB215500]
- National Natural Science Foundation of China [20825209, 21202189]
- Chinese Academy of Sciences
A new method for aromatic monofluoromethylation was developed. Aryl iodides can be efficiently transformed into the corresponding monofluoromethylated products by a copper-catalyzed debenzoylative fluoroalkylation with 2-PySO2CHFCOR and subsequent reductive desulfonylation. The (2-pyridyl)sulfonyl moiety plays an important role in the copper-catalyzed cross-coupling, and it can be removed easily through Bu3SnH-mediated desulfonylation.
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