期刊
NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-018-06393-w
关键词
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资金
- Academy of Finland [1268643, 258439, 283088]
- Sigrid Juselius Foundation
- Turku University Hospital EVO research funding
- EVO research funding of Turku University Hospital
- Finnish Society for Pediatric Research
- International Academic Meetings
- Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS) [2016-00768]
- MBDP doctoral program at the University of Helsinki
- Academy of Finland (AKA) [283088, 258439, 283088] Funding Source: Academy of Finland (AKA)
- Formas [2016-00768] Funding Source: Formas
The infant gut microbiota has a high abundance of antibiotic resistance genes (ARGs) compared to adults, even in the absence of antibiotic exposure. Here we study potential sources of infant gut ARGs by performing metagenomic sequencing of breast milk, as well as infant and maternal gut microbiomes. We find that fecal ARG and mobile genetic element (MGE) profiles of infants are more similar to those of their own mothers than to those of unrelated mothers. MGEs in mothers' breast milk are also shared with their own infants. Termination of breastfeeding and intrapartum antibiotic prophylaxis of mothers, which have the potential to affect microbial community composition, are associated with higher abundances of specific ARGs, the composition of which is largely shaped by bacterial phylogeny in the infant gut. Our results suggest that infants inherit the legacy of past antibiotic consumption of their mothers via transmission of genes, but microbiota composition still strongly impacts the overall resistance load.
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