4.8 Article

Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo

期刊

NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -

出版社

NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-06368-x

关键词

-

资金

  1. MRC [J000655, M010465]
  2. BBSRC [M008517]
  3. Wellcome Trust [084247/Z/07/Z]
  4. D.F.G. [SCHA965/9-1, SCHA965/6-2]
  5. Latsis Postgraduate Scholarship
  6. DAAD
  7. Boehringer Ingelheim Funds
  8. Company of Biologists
  9. EMBO [LTF-971]
  10. Marie Sklodowska Curie program [IF-2014_ST 658536]
  11. BBSRC [BB/R00627X/1] Funding Source: UKRI
  12. Wellcome Trust [084247/Z/07/Z] Funding Source: Wellcome Trust

向作者/读者索取更多资源

Connexins are the primary components of gap junctions, providing direct links between cells under many physiological processes. Here, we demonstrate that in addition to this canonical role, Connexins act as transcriptional regulators. We show that Connexin 43 (Cx43) controls neural crest cell migration in vivo by directly regulating N-cadherin transcription. This activity requires interaction between Cx43 carboxy tail and the basic transcription factor-3, which drives the translocation of Cx43 tail to the nucleus. Once in the nucleus they form a complex with Polll which directly binds to the N-cadherin promoter. We found that this mechanism is conserved between amphibian and mammalian cells. Given the strong evolutionary conservation of connexins across vertebrates, this may reflect a common mechanism of gene regulation by a protein whose function was previously ascribed only to gap junctional communication.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据