期刊
NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-05377-0
关键词
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资金
- ISEF foundation
- NIH [R01AG031164, R01AG054019, RF1AG054019, R01MH093537]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH093537] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [RF1AG054019, R01AG031164] Funding Source: NIH RePORTER
Loneliness and social isolation markedly increase mortality risk, and are linked to numerous mental and physical comorbidities, including sleep disruption. But does sleep loss causally trigger loneliness? Here, we demonstrate that a lack of sleep leads to a neural and behavioral phenotype of social withdrawal and loneliness; one that can be perceived by other members of society, and reciprocally, makes those societal members lonelier in return. We propose a model in which sleep loss instigates a propagating, self-reinforcing cycle of social separation and withdrawal.
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