期刊
NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-06310-1
关键词
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资金
- DFG fellowship through the Graduate School of Quantitative Biosciences Munich (QBM)
- DFG Collaborative Research Centre Spatiotemporal dynamics of bacterial cells [TRR 174/2017]
- MaxSynBio via German Federal Ministry of Education and Research (BMBF)
- Max Planck Society
- excellence cluster Nanosystems Initiative Munich
- International Max Planck Research School for Molecular Life Sciences
- Joachim Herz Foundation through an Add-on Fellowship
- Center for NanoScience Munich
- [GRK 2062]
The E. coli MinCDE system has become a paradigmatic reaction-diffusion system in biology. The membrane-bound ATPase MinD and ATPase-activating protein MinE oscillate between the cell poles followed by MinC, thus positioning the main division protein FtsZ at midcell. Here we report that these energy-consuming MinDE oscillations may play a role beyond constraining MinC/FtsZ localization. Using an in vitro reconstitution assay, we show that MinDE self-organization can spatially regulate a variety of functionally completely unrelated membrane proteins into patterns and gradients. By concentration waves sweeping over the membrane, they induce a direct net transport of tightly membrane-attached molecules. That the MinDE system can spatiotemporally control a much larger set of proteins than previously known, may constitute a MinC-independent pathway to division site selection and chromosome segregation. Moreover, the here described phenomenon of active transport through a traveling diffusion barrier may point to a general mechanism of spatiotemporal regulation in cells.
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