期刊
NATURE COMMUNICATIONS
卷 5, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms6028
关键词
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资金
- Air Force Office of Scientific Research [FA9550-12-1-0190]
- MSIP (Ministry of Science, ICT and Future Planning), Korea [NIPA 2014 H0201 14 1001]
- Agency for Science Technology and Research (A*STAR) Singapore for the National Science Scholarship (NSS)
- Stanford Center for Integrated Systems (CIS)
- Keck Foundation through the W.M. Keck Foundation Faculty Scholar Award
- Ministry of Public Safety & Security (MPSS), Republic of Korea [H0201-14-1001] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Continuous monitoring of internal physiological parameters is essential for critical care patients, but currently can only be practically achieved via tethered solutions. Here we report a wireless, real-time pressure monitoring system with passive, flexible, millimetre-scale sensors, scaled down to unprecedented dimensions of 1 x 1 x 0.1 cubic millimeters. This level of dimensional scaling is enabled by novel sensor design and detection schemes, which overcome the operating frequency limits of traditional strategies and exhibit insensitivity to lossy tissue environments. We demonstrate the use of this system to capture human pulse waveforms wirelessly in real time as well as to monitor in vivo intracranial pressure continuously in proof-of-concept mice studies using sensors down to 2.5 x 2.5 x 0.1 cubic millimeters. We further introduce printable wireless sensor arrays and show their use in real-time spatial pressure mapping. Looking forward, this technology has broader applications in continuous wireless monitoring of multiple physiological parameters for biomedical research and patient care.
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