期刊
NATURE COMMUNICATIONS
卷 5, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms6746
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资金
- University of Warwick
- Swiss National Science Foundation
- EPSRC
- Royal Society
- Engineering and Physical Sciences Research Council [EP/G004897/1]
- Warwick Centre for Analytical Science [EP/F034210/1]
- Science City Research Alliance
- HEFCE Strategic Development Fund
- Birmingham Science City
- Advantage West Midlands
- European Regional Development Fund
- Engineering and Physical Sciences Research Council [EP/G004897/1, EP/F034210/1] Funding Source: researchfish
- EPSRC [EP/F034210/1, EP/G004897/1] Funding Source: UKRI
Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each homochiral material. Herein, we report the preparation of stereocomplex micelles from a mixture of poly(L-lactide)-b-poly(acrylic acid) and poly(D-lactide)-b-poly(acrylic acid) diblock copolymers in water via crystallization-driven self-assembly. During the formation of these stereocomplex micelles, an unexpected morphological transition results in the formation of dense crystalline spherical micelles rather than cylinders. Furthermore, mixture of cylinders with opposite homochirality in either THF/H2O mixtures or in pure water at 65 degrees C leads to disassembly into stereocomplexed spherical micelles. Similarly, a transition is also observed in a related PEO-b-PLLA/PEO-b-PDLA system, demonstrating wider applicability. This new mechanism for morphological reorganization, through competitive crystallization and stereocomplexation and without the requirement for an external stimulus, allows for new opportunities in controlled release and delivery applications.
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