期刊
NATURE COMMUNICATIONS
卷 5, 期 -, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/ncomms6023
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资金
- LABEX WIFI (Laboratory of Excellence within the French Program 'Investments for the Future') [ANR-10-IDEX-0001-02 PSL]
- National Agency for Research under the programme 'future investments' [ANR-10-EQPX-15]
- European Research Council (ERC) Advanced Grant FUSIMAGINE
- Basque Country Government
Long-range coherences in spontaneous brain activity reflect functional connectivity. Here we propose a novel, highly resolved connectivity mapping approach, using ultrafast functional ultrasound (fUS), which enables imaging of cerebral microvascular haemodynamics deep in the anaesthetized rodent brain, through a large thinned-skull cranial window, with pixel dimensions of 100 mu m x 100 mu m in-plane. The millisecond-range temporal resolution allows unambiguous cancellation of low-frequency cardio-respiratory noise. Both seed-based and singular value decomposition analysis of spatial coherences in the low-frequency (<0.1 Hz) spontaneous fUS signal fluctuations reproducibly report, at different coronal planes, overlapping high-contrast, intrinsic functional connectivity patterns. These patterns are similar to major functional networks described in humans by resting-state fMRI, such as the lateral task-dependent network putatively anticorrelated with the midline default-mode network. These results introduce fUS as a powerful novel neuroimaging method, which could be extended to portable systems for three-dimensional functional connectivity imaging in awake and freely moving rodents.
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