期刊
NATURE COMMUNICATIONS
卷 5, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms4097
关键词
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资金
- R25T Molecular Imaging Fellowship: Molecular Imaging Training in Oncology [5R25CA096945-07]
- SNM Postdoctoral Molecular Imaging Scholar Award
- Steven Wynn Prostate Cancer Foundation-Young Investigator Award (PCF-YIA)
- David H. Koch PCF-YIA
- Geoffrey Beene Cancer Research Center of MSKCC
- Center for Targeted Radioimmunotherapy and Diagnosis of the Ludwig Center for Cancer Immunotherapy
- Department of Defense Prostate Cancer Research Program of the Congressionally Directed Medical Research Programs [W81XWH-12-1-0509]
- Starr Cancer Consortium [I4-A427]
- Louis V. Gerstner Young Investigator Award
- NIH [1R01EB014944-01, R24 CA83084, P30 CA08748]
- NATIONAL CANCER INSTITUTE [P30CA008748, P50CA086438, R24CA083084, R25CA096945] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB014944] Funding Source: NIH RePORTER
The invasion status of tumour-draining lymph nodes (LNs) is a critical indicator of cancer stage and is important for treatment planning. Clinicians currently use planar scintigraphy and single-photon emission computed tomography (SPECT) with Tc-99m-radiocolloid to guide biopsy and resection of LNs. However, emerging multimodality approaches such as positron emission tomography combined with magnetic resonance imaging (PET/MRI) detect sites of disease with higher sensitivity and accuracy. Here we present a multimodal nanoparticle, Zr-89-ferumoxytol, for the enhanced detection of LNs with PET/MRI. For genuine translational potential, we leverage a clinical iron oxide formulation, altered with minimal modification for radiolabelling. Axillary drainage in naive mice and from healthy and tumour-bearing prostates was investigated. We demonstrate that Zr-89-ferumoxytol can be used for high-resolution tomographic studies of lymphatic drainage in preclinical disease models. This nanoparticle platform has significant translational potential to improve preoperative planning for nodal resection and tumour staging.
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