期刊
NATURE COMMUNICATIONS
卷 4, 期 -, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/ncomms3771
关键词
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资金
- MRC through the MRC Sudden Death Brain Bank [G0802462]
- King Faisal Specialist Hospital and Research Centre, Saudi Arabia
- Intramural Research Program of the National Institute on Aging, National Institutes of Health, part of the US Department of Health and Human Services [ZIA AG000932-04]
- National Institute of Neurological Disorders and Stroke [U24 NS072026]
- National Institute on Aging [P30 AG19610]
- Arizona Department of Health Services [211002]
- Arizona Biomedical Research Commission [4001, 0011, 05-901, 1001]
- Michael J. Fox Foundation for Parkinson's Research
- National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust
- National Institute for Health Research (NIHR) Biomedical Research Centre at King's College London
- MRC [G0802462, MR/K01417X/1, G0901254, MR/L016400/1, MC_G1000735] Funding Source: UKRI
- Medical Research Council [MC_G1000735, G0901254, MR/K01417X/1, G0802462, MR/J006742/1, MR/L016400/1] Funding Source: researchfish
- National Institute for Health Research [ACF-2012-17-017, ACF-2007-18-011] Funding Source: researchfish
- Parkinson's UK [G-0907] Funding Source: researchfish
There is strong evidence to show that men and women differ in terms of neurodevelopment, neurochemistry and susceptibility to neurodegenerative and neuropsychiatric disease. The molecular basis of these differences remains unclear. Progress in this field has been hampered by the lack of genome-wide information on sex differences in gene expression and in particular splicing in the human brain. Here we address this issue by using post-mortem adult human brain and spinal cord samples originating from 137 neuropathologically confirmed control individuals to study whole-genome gene expression and splicing in 12 CNS regions. We show that sex differences in gene expression and splicing are widespread in adult human brain, being detectable in all major brain regions and involving 2.5% of all expressed genes. We give examples of genes where sex-biased expression is both disease-relevant and likely to have functional consequences, and provide evidence suggesting that sex biases in expression may reflect sex-biased gene regulatory structures.
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