期刊
NATURE COMMUNICATIONS
卷 4, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms3856
关键词
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资金
- Austrian Science Fund FWF [Y277-B03]
- European Research Council (ERC StG 'EvoChlamy')
- NIH [GM094800B, AI059327, GM051986]
- Caltech Center for Environmental Microbiology Interactions
- Gordon and Betty Moore Foundation
- BBSRC [BB/I020012/1]
- Austrian Science Fund (FWF) [Y 277] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/I020012/1] Funding Source: researchfish
- BBSRC [BB/I020012/1] Funding Source: UKRI
Chlamydiae are important pathogens and symbionts with unique cell biological features. They lack the cell-division protein FtsZ, and the existence of peptidoglycan (PG) in their cell wall has been highly controversial. FtsZ and PG together function in orchestrating cell division and maintaining cell shape in almost all other bacteria. Using electron cryotomography, mass spectrometry and fluorescent labelling dyes, here we show that some environmental chlamydiae have cell wall sacculi consisting of a novel PG type. Treatment with fosfomycin (a PG synthesis inhibitor) leads to lower infection rates and aberrant cell shapes, suggesting that PG synthesis is crucial for the chlamydial life cycle. Our findings demonstrate for the first time the presence of PG in a member of the Chlamydiae. They also present a unique example of a bacterium with a PG sacculus but without FtsZ, challenging the current hypothesis that it is the absence of a cell wall that renders FtsZ non-essential.
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