期刊
NATURE COMMUNICATIONS
卷 4, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms2807
关键词
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资金
- Molecular and Cell Biology Program of the Russian Academy of Sciences
- Russian Foundation for Basic Research
S1 is the largest ribosomal protein, and is vitally important for the cell. S1 is also a subunit of Q beta replicase, the RNA-directed RNA polymerase of bacteriophage Q beta. In both protein and RNA syntheses, S1 is commonly believed to bind to a template RNA at the initiation step, and not to be involved in later events. Here, we show that in Q beta replicase-mediated RNA synthesis, S1 functions at the termination step by promoting release of the product strand in a single-stranded form. This function is fulfilled by the N-terminal fragment comprising the first two S1 domains. The results suggest that S1 might also have a role other than mRNA binding in the ribosome.
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