期刊
NATURE COMMUNICATIONS
卷 3, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms1705
关键词
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资金
- NIH [1R01-HL098437]
- US-Israel Binational Science Foundation [2008137]
- Office of Naval Research (ONR) [000141010078]
- Israel Science Foundation
- European Community [DAPHNet/FP6 IST 018474-2, SOCIONICAL/FP7 ICT 231288]
- Brigham and Women's Hospital Biomedical Research Institute
- German Academic Exchange Service (DAAD)
The human organism is an integrated network where complex physiological systems, each with its own regulatory mechanisms, continuously interact, and where failure of one system can trigger a breakdown of the entire network. Identifying and quantifying dynamical networks of diverse systems with different types of interactions is a challenge. Here we develop a framework to probe interactions among diverse systems, and we identify a physiological network. We find that each physiological state is characterized by a specific network structure, demonstrating a robust interplay between network topology and function. Across physiological states, the network undergoes topological transitions associated with fast reorganization of physiological interactions on time scales of a few minutes, indicating high network flexibility in response to perturbations. The proposed system-wide integrative approach may facilitate the development of a new field, Network Physiology.
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