期刊
AUTOPHAGY
卷 11, 期 3, 页码 538-546出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2015.1017186
关键词
autophagy; BAG3; chaperone; exercise; HSPB8; human subjects; mechanical tension; muscle; proteostasis; stress; CASA; chaperone-assisted selective autophagy; CK; creatine kinase; TBS; tris-buffered saline
类别
资金
- DFG [SFB 635 TP8, SFB 645 TPC6, FOR 1352]
- BISP [IIA1-070112/13-14, IIA1-070103/09-10]
Chaperone-assisted selective autophagy (CASA) is a tension-induced degradation pathway essential for muscle maintenance. Impairment of CASA causes childhood muscle dystrophy and cardiomyopathy. However, the importance of CASA for muscle function in healthy individuals has remained elusive so far. Here we describe the impact of strength training on CASA in a group of healthy and moderately trained men. We show that strenuous resistance exercise causes an acute induction of CASA in affected muscles to degrade mechanically damaged cytoskeleton proteins. Moreover, repeated resistance exercise during 4 wk of training led to an increased expression of CASA components. In human skeletal muscle, CASA apparently acts as a central adaptation mechanism that responds to acute physical exercise and to repeated mechanical stimulation.
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