期刊
ONCOLOGY LETTERS
卷 9, 期 1, 页码 270-274出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2014.2685
关键词
bisdemethoxycurcumin; gastric adenocarcinoma; tumor growth inhibition; apoptosis; mitochondria
类别
资金
- National Natural Science Foundation of China [81172295]
- Chongqing Medical University
- Lanzhou University Second Hospital
Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin. In this study, a human gastric adenocarcinoma xenograft model was generated in vivo using nude mice and BDMC was observed to suppress the growth and activity of tumors, in addition to improving the physical and mental capacity of the mice. An increased number of apoptotic cells, decreased ratio of B-cell lymphoma 2 (Bcl-2)/Bcl-2-associated X protein and increased caspase-3 expression was also observed following treatment with BDMC, indicating that BDMC may promote apoptosis in tumors via mitochondrial modulation. The growth of SGC 7901 gastric cancer cells was inhibited and arrested at G(1) phase. Specific indicators of mitochondrial dysfunction, a reduction in adenosine triphosphate generation, the inner mitochondrial membrane potential, augmentation of reactive oxygen species production and cytochrome c were also detected in the mitochondria following treatment with BDMC. These results indicate that BDMC attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction.
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