期刊
ONCOLOGY LETTERS
卷 5, 期 2, 页码 675-680出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2012.1074
关键词
breast cancer; tumor cell-induced platelet aggregation; glycoprotein-Ib-IX; glycoprotein-IIb/IIIa; thromboxane A2; adenosine diphosphate
类别
资金
- National Natural Science Foundation of China [81101867, 81272542]
- China International Medical Foundation [CIMF-F-H001-057]
- Science and Education for Health Foundation of Suzhou for Youth [SWKQ1003]
Cancer metastasis is a highly coordinated and dynamic multistep process in which cancer cells interact with a variety of host cells. Morphological studies have documented the association of circulating tumor cells with host platelets. Tumor cell-induced platelet aggregation (TCIPA) contributes significantly to hematogenous metastasis; however, the molecular mechanisms involved in breast cancer TCIPA are poorly characterized. In this study, MCF-7 metastatic human breast cancer cells induced dose-dependent aggregation of washed platelets. Four major platelet activation pathways, glycoprotein (GP)-Ib-IX, GPIIb/IIIa, thromboxane (TX)-A2 and adenosine diphosphate (ADP) were activated during TCIPA and were inhibited by their respective inhibitors, 7E3, SZ-1, aspirin and apyrase. Pretreatment of platelets with 7E3, SZ-1 or apyrase significantly inhibited TCIPA, while pretreatment with aspirin had no effect. Moreover, combined pretreatment of platelets with 7E3, SZ-1 and apyrase significantly inhibited TCIPA, compared to single inhibitors. Combinations of antiplatelet drugs may represent a promising strategy to prevent cancer metastasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据