期刊
ONCOLOGY LETTERS
卷 3, 期 5, 页码 961-969出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2012.628
关键词
gastrointestinal carcinomas; tissue microarray; immunohistochemistry; in situ hybridization; pathogenesis; pathobiological behaviors; prognosis
类别
资金
- Shenyang Outstanding Talent Foundation of China
- Shenyang Science and Technology Grant [1091175-1-00, F11-264-1-10]
- Liaoning Science and Technology Grant
- Natural Scientific Foundation of China [81001093, 81101885, 81101886, 81172371]
- Ministry of Education, Culture, Sports and Technology of Japan [23659958]
- Grants-in-Aid for Scientific Research [23659958] Funding Source: KAKEN
Gastrointestinal adenocarcinoma (GIA) is a common malignant disease worldwide. Its tumorigenesis and progression is a multistage process with the involvement of a multifactorial etiology. Knowledge regarding altered expression of these genes during carcinogenesis may not only provide information about the molecular events during the initiation and progression of cancer, but may also result in the discovery of biological markers for the evaluation of cancer diagnosis and prognosis. In this review, we assessed molecular markers of pathogenesis, invasion, metastasis and prognosis, such as tumor suppressor and metastasis suppressor genes, and angiogenesis, cell adhesion, cell mobility, ER stress, mucin production, threonine protein kinase and REG family protein expression, by the establishment of tissue microarray (TMA) of GIA and immunohistochemistry (IHC) by intermittent microwave irradiation and in situ hybridization (ISH). Finally, we characterized the pathobiological features of Lauren's and WHO subtypes. It was found that the aberrant and cell-specific expression of these molecules is important in the malignant transformation of gastrointestinal epithelium and subsequent progression. These molecules also underlie the histogenic mechanisms of gastric carcinoma according to Lauren's and WHO classification. The combination of TMA, IHC and ISH may be widely applied to screen for molecular markers in GIA.
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