期刊
CURRENT ONCOLOGY REPORTS
卷 12, 期 2, 页码 87-94出版社
SPRINGER
DOI: 10.1007/s11912-010-0091-6
关键词
Phosphoinositide-3 kinase; Targeted therapy.; Drug development
类别
资金
- NCI NIH HHS [U01 CA062490-16, U01 CA062490] Funding Source: Medline
The phosphoinositide-3 kinase (PI3K) pathway plays a critical role in cancer cell growth and survival. PI3K is activated in human cancers by elevated receptor tyrosine kinase activity, RAS mutation, as well as by mutation, amplification, and deletion of genes encoding components of the pathway. Additionally, PI3K pathway activation plays an important role in acquired resistance to both chemotherapy and targeted agents. The essential role of PI3K in human cancer has led to the development of PI3K pathway inhibitors that have shown promise in preclinical models and have entered phase 1 clinical trials. This article reviews preclinical and clinical data on members of this novel drug class, as well as data justifying the combination of PI3K inhibitors with other anticancer agents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据