期刊
EPIGENOMICS
卷 10, 期 8, 页码 1103-1119出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2018-0001
关键词
DNA methylation; extracellular matrix; gene expression; MFAP5; systems biological analysis; varicose vein(s); vascular remodeling
资金
- Russian Science Foundation [17-75-20223]
- SB RAS Complex scientific program [0309-2015-0028]
- Russian Science Foundation [17-75-20223] Funding Source: Russian Science Foundation
Aim: To integrate transcriptomic and DNA-methylomic measurements on varicose versus normal veins using a systems biological analysis to shed light on the interplay between genetic and epigenetic factors. Materials & methods: Differential expression and methylation were measured using microarrays, supported by real-time quantitative PCR and immunohistochemistry confirmation for relevant gene products. A systems biological 'upstream analysis' was further applied. Results: We identified several potential key players contributing to extracellular matrix remodeling in varicose veins. Specifically, our analysis suggests MFAP5 acting as a master regulator, upstream of integrins, of the cellular network affecting the varicose vein condition. Possible mechanism and pathogenic model were outlined. Conclusion: A coherent model proposed incorporates the relevant signaling networks and will hopefully aid further studies on varicose vein pathogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据