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PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
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A somatic EZH2 mutation in childhood acute myeloid leukemia
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent
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SCIENCE (2012)
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ACS MEDICINAL CHEMISTRY LETTERS (2012)
Development and Validation of Reagents and Assays for EZH2 Peptide and Nucleosome High-Throughput Screens
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JOURNAL OF BIOMOLECULAR SCREENING (2012)
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
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BLOOD (2011)
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BLOOD (2011)
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CANCER RESEARCH (2011)
Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker
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CANCER SCIENCE (2011)
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CARCINOGENESIS (2011)
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
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FEBS LETTERS (2011)
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HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2011)
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NATURE GENETICS (2011)
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EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis
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NATURE GENETICS (2010)
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
Thomas Ernst et al.
NATURE GENETICS (2010)
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
Christopher J. Sneeringer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98
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CELL DEATH & DISEASE (2010)
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ONCOTARGET (2010)
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MOLECULAR CANCER THERAPEUTICS (2009)
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
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NATURE GENETICS (2009)
Ezh2 requires PHF1 to efficiently catalyze h3 lysine 27 trimethylation in vivo
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MOLECULAR AND CELLULAR BIOLOGY (2008)
Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer
Sooryanarayana Varambally et al.
SCIENCE (2008)
High-resolution profiling of histone methylations in the human genome
Artern Barski et al.
CELL (2007)
Pharmacologic disruption of polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
Jing Tan et al.
GENES & DEVELOPMENT (2007)
The polycomb group protein Suz12 is required for embryonic stem cell differentiation
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MOLECULAR AND CELLULAR BIOLOGY (2007)
The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer
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GENES CHROMOSOMES & CANCER (2006)
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AP Bracken et al.
GENES & DEVELOPMENT (2006)
Control of developmental regulator's by polycomb in human embryonic stem cells
TI Lee et al.
CELL (2006)
EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
IM Bachmann et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma
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BRITISH JOURNAL OF CANCER (2005)
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex
R Cao et al.
MOLECULAR CELL (2004)
Increased expression of the EZH2 polycomb group gene in BMI-1-positive neoplastic cells during bronchial carcinogenesis
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NEOPLASIA (2004)
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
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EMBO JOURNAL (2003)
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
CG Kleer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Missense mutation and defective function of ATM in a childhood acute leukemia patient with MLL gene rearrangement
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BLOOD (2003)
Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement
IH Su et al.
NATURE IMMUNOLOGY (2003)
Role of histone H3 lysine 27 methylation in polycomb-group silencing
R Cao et al.
SCIENCE (2002)
The polycomb group protein EZH2 is involved in progression of prostate cancer
S Varambally et al.
NATURE (2002)
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T Reya et al.
NATURE (2001)
Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice
CWM Roberts et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Coexpression of BMI-1 and EZH2 polycomb group genes in Reed-Sternberg cells of Hodgkin's disease
FM Raaphorst et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)