期刊
EPIGENOMICS
卷 6, 期 4, 页码 427-443出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi.14.35
关键词
AID; APOBEC; deaminase; DNA demethylation; DNA repair; epigenetics; immunity
资金
- IFOM - Fondazione Istituto FIRC di Oncologia Molecolare, Italy
- DIVA - Discover Validation of Anticancer drugs, Lombardi, Italy
- Epigenomics Flagship Project - Progetto Bandiera Epigenomica (EPIGEN), Italy
- AIRC - Italian Association for Cancer research [13149]
DNA mutations and genomic recombinations are the origin of oncogenesis, yet parts of developmental programs as well as immunity are intimately linked to, or even depend on, such DNA damages. Therefore, the balance between deleterious DNA damages and organismal survival utilizing DNA editing (modification and repair) is in continuous flux. The cytosine deaminases AID/APOBEC are a DNA editing family and actively participate in various biological processes. In conjunction with altered DNA repair, the mutagenic potential of the family allows for APOBEC3 proteins to restrict viral infection and transposons propagation, while AID can induce somatic hypermutation and class switch recombination in antibody genes. On the other hand, the synergy between effective DNA repair and the nonmutagenic potential of the DNA deaminases can induce local DNA demethylation to support epigenetic cellular identity. Here, we review the current state of knowledge on the mechanisms of action of the AID/APOBEC family in immunity and epigenetics.
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