期刊
EPIGENOMICS
卷 4, 期 5, 页码 503-509出版社
FUTURE MEDICINE LTD
DOI: 10.2217/EPI.12.41
关键词
aging; EWAS; longevity; methylation
资金
- NIA NIH HHS [R01 AG042188] Funding Source: Medline
The aging phenotype is the result of a complex interaction between genetic, epigenetic and environmental factors. Evidence suggests that epigenetic changes (i.e., a set of reversible, heritable changes in gene function or other cell phenotype that occurs without a change in DNA sequence) may affect the aging process and may be one of the central mechanisms by which aging predisposes to many age-related diseases. The total number of altered methylation sites increases with increasing age, such that they could serve as marker for chronological age. This article systematically highlights the advances made in the field of epigenomics and their contribution to the understanding of the complex physiology of aging, lifespan and age-associated diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据