期刊
EPIGENETICS & CHROMATIN
卷 5, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/1756-8935-5-1
关键词
enhancer; silencer; insulator; transcription factory; hub; long-range interactions; chromosome conformation capture; three-dimensional genome architecture
资金
- ERASysBio+/FP7
- ERASysBio+
- Dutch Ministry for Science and Education
- Netherlands Science Organization
- UK Biotechnology and Biological Sciences Research Council
- High-Performance Computing Center Stuttgart (HumNuc)
- Supercomputing Center Karlsruhe (ChromDyn)
- Computing Facility of the German Cancer Research Center (DKFZ)
- Erasmus Computing Grid
- German Ministry for Science Technology [BMBF 01 KW 9602/2]
- German Human Genome Project [01AK803A]
- German MediGRID) [01IG07015G]
- European Commission [FP7 EDGEs]
- Biotechnology and Biological Sciences Research Council [BB/I00467X/1] Funding Source: researchfish
- BBSRC [BB/I00467X/1] Funding Source: UKRI
Regulatory DNA elements such as enhancers, silencers and insulators are embedded in metazoan genomes, and they control gene expression during development. Although they fulfil different roles, they share specific properties. Herein we discuss some examples and a parsimonious model for their function is proposed. All are transcription units that tether their target promoters close to, or distant from, transcriptional hot spots (or 'factories').
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