期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 9, 期 10, 页码 1035-1038出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.8b00334
关键词
Carbonic anhydrase; famotidine; Helicobacter pylori; inhibitor; metalloenzymes
Famotidine, an antiulcer drug incorporating a sulfamide motif, was investigated as carbonic anhydrase inhibitor (CAI). It acts as a nanomolar inhibitor of several human (hCA II, VI, VII and XII) and Helicobacter pylori CAs. The high resolution X-ray structures of famotidine bound to hCA I and II revealed interesting aspects related to its CA inhibition mechanism, offering the possibility to develop antibacterials with a novel mechanism of action.
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