期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 5, 期 1, 页码 2-5出版社
AMER CHEMICAL SOC
DOI: 10.1021/ml4004638
关键词
Ligand efficiency (LE); lipophilic efficiency (LipE); drug-likeness; efficiency metrics; decision making; fragment-based drug design
To increase the probability of success in drug discovery, the concept of drug-like properties was introduced. Efficiency metrics that normalize potency against these properties could help reach drug-like space more efficiently. Potential reasons for the inefficient use of metrics and suboptimal decision making are discussed.
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