期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 4, 期 12, 页码 1238-1243出版社
AMER CHEMICAL SOC
DOI: 10.1021/ml400382p
关键词
RIP1; type II kinase inhibitors; necroptosis
Potent inhibitors of RIP1 kinase from three distinct series, 1-aminoisoquinolines, pyrrolo[2,3-b]pyridines, and furo[2,3-d]pyrimidines, all of the type II class recognizing a DLG-out inactive conformation, were identified from screening of our in-house kinase focused sets. An exemplar from the furo[2,3-d]pyrimidine series showed a dose proportional response in protection from hypothermia in a mouse model of TNF alpha induced lethal shock.
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