期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 4, 期 2, 页码 288-292出版社
AMER CHEMICAL SOC
DOI: 10.1021/ml300429p
关键词
Candida; Aspergillus; zygomycetes; antifungal agents; azoles; thiazolo[4,5-g]quinazolin-8(7H)-one
资金
- Ministere de l'Enseignement Superieur et de la Recherche (MESR)
Synthesis of a strict structural analogue of albaconazole in which the quinazolinone ring is fused by a thiazole moiety led to the discovery of a new triazole with broad-spectrum antifungal activity. Compound I exhibited high in vitro activity against pathogenic Candida species and filamentous fungi and showed preliminary in vivo antifungal efficacy in a mice model of systemic candidiasis.
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