Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists

We report the discovery and characterization of natural phenols as G protein-coupled receptor-35 (GPR35) agonists. Pharmacological characterization using label-free dynamic mass redistribution and Tango beta-arrestin translocation assays revealed that GPR35-active natural phenols are divergent in their biased agonism.