期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 3, 期 8, 页码 683-686出版社
AMER CHEMICAL SOC
DOI: 10.1021/ml3001215
关键词
antimicrobial peptides; peptidomimetics; drug resistance; lipidation; alpha-AApeptides
资金
- USF
We report a series of lipidated alpha-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated alpha-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear alpha-AApeptides. The further development of lipidated alpha-AApeptides will lead to a new class of antibiotics to combat drug resistance.
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