期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 3, 期 2, 页码 135-139出版社
AMER CHEMICAL SOC
DOI: 10.1021/ml200259q
关键词
CX-6258; Pim-1; Pim-2; Pim-3; MV-4-11; PC3
Structure activity relationship analysis in a series of 3-(5-((2-oxoindolin-3-ylidene)methyl)furan-2-yl)amides identified compound 13, a pan-Pim kinases inhibitor with excellent biochemical potency and kinase selectivity. Compound 13 exhibited in vitro synergy with chemotherapeutics and robust in vivo efficacy in two Pim kinases driven tumor models.
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