期刊
ACS MEDICINAL CHEMISTRY LETTERS
卷 1, 期 7, 页码 331-335出版社
AMER CHEMICAL SOC
DOI: 10.1021/ml100096t
关键词
Phosphorylation; protozoans; calcium-dependent protein kinases; Cryptosporidium parvum; Toxoplasma gondii; apicomplexan
资金
- National Institute of Allergy and Infectious Diseases [R01 AI080625, R01 AI067921]
- National Institute of General Medical Sciences [R01 GM086858]
The protozoans Cryptosporidium parvum and Toxoplasma gondii are parasites of major health concern to humans. Both parasites contain a group of calcium dependent protein kinases (CDPKs) which are found in plants and ciliates but not in humans or fungi. Here, we describe a series of potent inhibitors that target CDPK1 in C. parvum (CpCDPK1) and T. gondii (TgCDPK1). These inhibitors are highly selective for CpCDPK1 and TgCDPK1 over the mammalian kinases SRC and ABL. Furthermore, they are able to block an early stage of C. parvum invasion of HCT-8 host cells, which is similar to their effects on T. gondii invasion of human fibroblasts.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据