Mitochondrial network energetics in the heart

At the core of eukaryotic aerobic life, mitochondrial function like hubs in the web of energetic and redox processes in cells. In the heart, these networksextending beyond the complex connectivity of biochemical circuit diagrams and apparent morphologyexhibit collective dynamics spanning several spatiotemporal levels of organization, from the cell, to the tissue, and the organ. The network function of mitochondria, i.e., mitochondrial network energetics, represents an advantageous behavior. Its coordinated action, under normal physiology, provides robustness despite failure in a few nodes, and improves energy supply toward a swiftly changing demand. Extensive diffuse loops, encompassing mitochondrialcytoplasmic reaction/transport networks, control and regulate energy supply and demand in the heart. Under severe energy crises, the network behavior of mitochondria and associated glycolytic and other metabolic networks collapse, thereby triggering fatal arrhythmias. WIREs Syst Biol Med 2012, 4:599613. doi: 10.1002/wsbm.1188 For further resources related to this article, please visit the WIREs website.