期刊
EXPERIMENTAL AND THERAPEUTIC MEDICINE
卷 16, 期 4, 页码 3099-3106出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2018.6579
关键词
pulmonary thromboembolism; platelet-derived microparticles; D-dimer; receiver operating characteristic
资金
- Shenzhen Science and Technology Project, China [20150314104846179, JCYJ20170413093032806]
- Shenzhen Key Laboratory of Respiratory Disease [ZDSYS201504301616234]
- Guangdong Science and Technology Project, China [2017A020214016]
An early and accurate diagnosis of pulmonary thromboembolism (PTE) remains challenging. The present study aimed to evaluate the diagnostic value of platelet-derived microparticles in PTE based on a population study. A total of 102 patients with PTE, 102 healthy controls and 40 patients suspected with PTE were enrolled in this study. The platelet count, mean platelet volume and platelet distribution width were assessed using an automated hematology analyzer, P-selectin was assessed using an ELISA kit and PMPs were explored using flow cytometry using Megamix beads. Receiver operating characteristic curves were established to evaluate the diagnostic values of PMPs, D-dimer, PMPs combined with D-dimer, and multiple parameters (including PMPs, platelet distribution width, P-selectin and D-dimer in PTE). The PMP levels were significantly higher in the patients with PTE (609.10/mu l) compared with those in the healthy controls (230.60/mu l) and patients with suspicious PTE (166.70/mu l; P<0.01). The accuracy (72.06%) of PMPs in the diagnosis of PTE was similar to those of D-dimer (P>0.05). The combination of D-dimer and PMPs significantly increased the sensitivity (86.27%) of D-dimer and the specificity of PMP for the diagnosis of PTE (P<0.01). The combination of PMPs, platelet distribution width, P-selectin and D-dimer exhibited high sensitivity (88.24%), specificity (91.18%) and accuracy (89.71%) in the diagnosis of PTE. These findings suggest that elevated PMP levels are an effective predictor of PTE. The combination of PMPs, platelet distribution width, P-selectin and D-dimer may be used in the diagnosis of PTE with high sensitivity and specificity.
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