期刊
EXPERIMENTAL AND THERAPEUTIC MEDICINE
卷 9, 期 3, 页码 905-908出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2014.2150
关键词
hepatocellular carcinoma; androgen receptor; matrix metalloproteinase-2; matrix metalloproteinase-9
The aim of the present study was to investigate the potential roles of the androgen receptor (AR) and matrix metalloproteinase (MMP)-2 and MMP-9 in hepatocellular carcinoma (HCC) tissues and whether their expression could be used as a predictor of the invasion and stage of cancer. The expression levels of AR, MMP-2 and MMP-9 in HCC tissues and tissues adjacent to the tumor were measured by immunohistochemical staining assay. The expression rates of AR, MMP-2 and MMP-9 in the HCC tissue were 76.67, 73.33 and 76.67%, respectively, all of which were significantly higher than those in the tissues adjacent to the tumor. The expression of these proteins represents the local invasion and stage. AR, MMP-2 and MMP-9 expression levels in HCC tissues have the potential to be employed as predictors of the progression of local cancer invasion and the tumor stage.
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