期刊
EXPERIMENTAL AND THERAPEUTIC MEDICINE
卷 7, 期 2, 页码 365-370出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2013.1434
关键词
nuclear factor-kappa B; glutamine; nonalcoholic fatty liver disease; oxidative stress
The aim of this study was to investigate the effects of glutamine on the histomorphology of the liver, oxidative stress and nuclear factor-kappa B (NF-kappa B) expression in the development of nonalcoholic fatty liver disease (NAFLD). NAFLD was induced in rats by a high-fat diet, and rats in the treatment group were subjected to oral administration of glutamine (1 g/kg/day). Rats from the treatment, model and normal control groups were assessed after 8 and 12 weeks (n=6 per group at each time-point). The levels of glutathione (GSH), malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-alpha) in the liver, and the liver histopathology and NF-kappa B protein 65 (p65) expression in the liver were assessed. Compared with the control group under the same experimental period, the MDA and TNF-alpha levels in the liver, the hepatic steatosis and the hepatic expression of NF-kappa B p65 were significantly higher in the model and the treatment groups (P<0.05), while the GSH levels in the liver were significantly lower (P<0.05). These indices improved significantly in the treatment group compared with the model group (P<0.05). In conclusion, glutamine reduces the degree of oxidative stress in the liver, inhibits NF-kappa B p65 expression and improves hepatic steatosis. Glutamine has a certain protective effect in NAFLD.
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